R&D

Research into the materials and functions

Major Research Findings (Submitted papers)

2018

Nov. 2018

Taxonomic classification for microbiome analysis, which correlates well with the metabolite milieu of the gut

BMC Microbiol., 18, 188 / Yoshihisa Wakita
Sep. 2018

Quantitative evaluation of the hop (Humulus lupulus L.) root system based on wall profile method.

Plant Root, 12:11-15 / Koie K, Miyoda T, Yoshida H, Itoh H
Jul. 2018

Breeding of lipoxygenase-1-less malting barley variety ‘SouthernStar’ and evaluation of malting and brewing quality

Journal of Cereal Science, 83, 83-89 / Takehiro Hoki, Wataru Saito, Takashi Iimure, Naohiko Hirota, Kiyoshi Takoi, Masayuki Shimase, Stewart Coventry, Timothy March, Amanda Box, Jason Eglinton, Makoto Kihara, Kensuke Ogushi
Jul. 2018

Effects of Oral Calcium Dosage and Timing on Ethanol-induced Sensitization of Locomotion in DBA/2 Mice.

Biol Pharm Bull., 41, 1049-1061 / Shimizu C, Mitani Y, Tsuchiya Y, Nabeshima T
May. 2018

Breeding of lipoxygenase-1-less malting barley variety ‘Satuiku 2 go’

Journal of the Institute of Brewing, 124, 112-120 / Takehiro Hoki, Ryoichi Kanatani, Wataru Saito, Takashi Iimure, Tian-su Zhou, Kiyoshi Takoi, Atsushi Tanigawa, Makoto Kihara and Kensuke Ogushi

2017

Jun. 2017

The Effects of a Calcium-Fortified Lemon Drink on Bone Density and Bone Metabolism in Postmenopausal Women

International Medical Journal, Vol.24, No.3, pp.279-283 / Masanori Hiramitsu / 共著 県立安芸津病院、県立広島大学
Jun. 2017

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Journal of Nutritional Science and Vitaminology, Vol.63, No.3, p.200-207 / Masanori HIRAMITSU / 共著 名古屋大学
Apr. 2017

Xanthohumol, a Hop-Derived Prenylated Flavonoid, Promotes Macrophage Reverse Cholesterol Transport

The Journal of Nutritional Biochemistry, 47, 29-34, / Hiroshi Hirata

2016

Nov. 2016

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Experimental and Therapeutic Medicine https://www.spandidos-publications.com/etm/12/6/3863 / Masahiro Ogawa
Oct. 2016

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

J Pharm Pharm Sci (www.cspsCanada.org), 19(4), 430 - 447 / C. Shimizu
Sep. 2016

Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study

Beneficial Microbes, 7(4), 501 - 509 / Yasukazu Nakakita
May. 2016

A Lactobacillus mutant capable of accumulating long-chain polyphosphates that enhance intestinal barrier function

Bioscience, Biotechnology, and Biochemistry, 80(5), 955-961 / Asako Saiki

2015

Sep. 2015

Factors Affecting Ethanol-induced Conditioned Place Preference and Locomotor Sensitization in Mice

Biol. Pharm. Bull., 38, 1935–1945 / C. Shimizu
Apr. 2015

Purification of Barley Dimeric α-Amylase Inhibitor-1 (BDAI-1) and Avenin-like Protein-a (ALP) from Beer and Their Impact on Beer Foam Stability.

Food Chemistry, 172, 257-264 / Takashi Iimure
2015

LOX-less malting barley varieties and their effects on beer quality

Brauwelt International, 2 / Takehiro Hoki

2014

Apr. 2014

Effect on Blood Pressure of Daily Lemon Ingestion and Walking

Journal of Nutrition and Metabolism, Vol 2014, Article ID 912684, 6 pages / Masanori Hiramitsu / 共著 名古屋大学
Jan. 2014

Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

Scientific Reports, 4, 3708, 11 pages / Masanori Hiramitsu / 共著 三重大学
2014

Development of CAPS marker and its use for malting barley breeding

「Cleaved Amplified Polymorphism Sequence (CAPS) Marker in Plant Biology」 (Nova Science Publishers, Inc.) / Takashi Iimure, Tian-su Zhou, Takehiro Hoki

2013

Dec. 2013

Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells

Medical Molecular Morphology, 46(4), 203-209 / J. Fuchimoto
Aug. 2013

Heat-killed Lactobacillus brevis SBC8803 induces serotonin release from intestinal cells

Food and Nutrition Sciences, 4(8), 767-771 / Y. Nakakita
2013

Breeding of Lipoxygenase-1-less Malting Barley Variety CDC PolarStar and Effect of Lipoxygenase-1-less Trait on Beer Quality at Pilot and Commercial Scale Brewing

BrewingScience, 66, 37-45 / Takehiro Hoki, Wataru Saito, Naohiko Hirota, Masanori Shirai, Kiyoshi Takoi, Shinichiro Yoshida, Masayuki Shimase, Tetsuya Saito, Tomokazu Takaoka, Makoto Kihara, Shinji Yamada

Beer proteomics analysis for beer quality control and malting barley Breeding

(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Institute of Plant Science and Resources, Okayama University, JAPAN
Food Research International, 54, 1013-1020 / Takashi Iimure (1), Kazuhiro Sato (2)

Beer and wort proteomics

(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Institute of Plant Science and Resources, Okayama University, JAPAN
In J. V. Jorrin-Novo, S. Komatsu, W. Weckwerth, & S. Wienkoop (Eds), Plant Proteomics, Methods in Molecular Biology, 1072, pp 737-754, Humana Press. / Takashi Iimure (1), Makoto Kihara (1), Kazuhiro Sato (2)

Beer proteomics

In Toldrá F, Leo M. L. Nollet L M L (Ed), Proteomics in Foods, Food Microbiology and Food Safety, pp 399-424, Springer. / Takashi Iimure

2012

Dec. 2012

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Journal of Nutritional Science and Vitaminology, 58(6), 408-414 / Masanori HIRAMITSU※ / 共著 名古屋大学
Nov. 2012

Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells

American Journal of Rhinology and Allergy, 26(6), 433-438 / J. Fuchimoto

Xanthohumol Prevents Atherosclerosis by Reducing Arterial Cholesterol Content via CETP and Apolipoprotein E in CETP-Transgenic Mice

PLoS One, 7(11), e49415 / H. Hirata
Oct. 2012

Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein

Food Chemistry, 134(3), 1432-1437 / H. Hirata
Jun. 2012

Effects of Citric Acid and Lemon Juice on Iron Absorption and Improvement of Anemia in Iron-Deficient Rats

Food Science and Technology Research, Vol.18, No.1, pp127-130 / Koji Takatera※
May. 2012

Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study

Food and Nutrition Sciences, 3(5), 678-684 / Y. Wakita
2012

Proteome analysis of the wort boiling process

Food Research International, 45, 262-271 / Takashi Iimure (1), Nami Nankaku (2), Makoto Kihara (1), Shinji Yamada (1), Kazuhiro Sato (2)
(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Institute of Plant Science and Resources, Okayama University, JAPAN

Mutation Analysis of Barley Malt Protein Z4 and Protein Z7 on Beer Foam Stability

Journal of Agricultural and Food Chemistry, 60, 1548-1554 / Takashi Iimure (1), Tatsuji Kimura (2), Shigeki Araki (2), Makoto Kihara (1), Masahide Sato (2), Shinji Yamada (1), Tatsuro Shigyou (2), and Kazuhiro Sato (3)
(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., Japan
(3) Institute of Plant Science and Resources, Okayama University, JAPAN

2011

Dec. 2011

Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet

Bioscience, Biotechnology, and Biochemistry, 75(12), 2309-2315 / Masanori HIRAMITSU※ / 共著 名古屋大学
Aug. 2011

Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin?p38 MAPK pathway activation.

PLoS One, 6(8), e23278 / S. Segawa
2011

Development of DNA Markers Associated with Beer Foam Stability for Barley Breeding

Theoretical and Applied Genetics, 122, 199-210 / Takashi Iimure (1), Makoto Kihara (1), Seiichiro Ichikawa (1), Kazutoshi Ito (1), Kazuyoshi Takeda (2) and Kazuhiro Sato (2)
(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Institute of Plant Science and Resources, Okayama University,JAPAN

2010

May. 2010

Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice.

Journal of Agricultural and Food Chemistry, 58(9), 5597-603 / Inoue T,※ / 共著 名古屋大学
2010

Construction of a novel beer proteome map and its use in beer quality control

Food Chemistry, 118, 566-574 / Takashi Iimure (1), Nami Nankaku (2), Naohiko Hirota (1), Zhou Tiansu (1), Takehiro Hoki (1), Makoto Kihara (1), Katsuhiro Hayashi (1), Kazutoshi Ito (1), Kazuhiro Sato (2)
(1) Bioresources Research and Development Department, Sapporo Breweries Ltd., JAPAN
(2) Institute of Plant Science and Resources, Okayama University, JAPAN

2009

Jan. 2009

Preparation of a Lemon Flavonoid Aglycone and its Suppressive Effect on the Susceptibility of LDL to Oxidation Following Human Ingestion

Food Science and Technology Research, 15(1), 83-88 / Yoshiaki MIYAKE※ / 共著 お茶の水女子大学
2009

Components of lemon essential oil attenuate dementia induced by scopolamine.

Nutritional Neuroscience, 12, 57-64 / Shuuichi Fukumoto※ / 共著 静岡県立大学

2008

Nov. 2008

Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue

Journal of Clinical Biochemistry and Nutrition 43・3・201-209 / Masanori Hiramitsu※ / 共著 名古屋大学、椙山女学園大学
2008

Effect of flavor components in lemon essential oil on physical or psychological stress.

Stress and health, 24, 3-12 / Shuuichi Fukumoto※ / 共著 静岡県立大学

Effects of direct exposure of green odour components on dopamine release from rat brain striatal slices and PC12 cells.

Brain Res Bull., 75, 706-712 / Shuuichi Fukumoto※ / 共著 静岡県立大学

2007

Aug. 2007

Isolation of Antioxidative Phenolic Glucosides from Lemon Juice and Their Suppressive Effect on the Expression of Blood Adhesion Molecules

Bioscience, Biotechnology, and Biochemistry, 71(8), 1911-1919 / Yoshiaki MIYAKE※ / 共著 名古屋大学

2006

Brewing Performance of Malted Lipoxygenase-1 Null Barley and Effect on the Flavor Stability of Beer.

Cereal Chemistry, 83, 250-254 (2006) / Naohiko Hirota, Hisao Kuroda, Kiyoshi Takoi, Takafumi Kaneko, Hirotaka Kaneda, Ikuya Yoshida, Masachika Takashio, Kazutoshi Ito, Kazuyoshi Takeda*
*Okayama University, Okayama, Japan.

2005

Characterization of lipoxygenase-1 null mutants in barley

Theoretical and Applied Genetics, 111, 1580-1584 (2005) / Naohiko Hirota, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Masachika Takashio, Kazutoshi Ito, Kazuyoshi Takeda*
*Okayama University, Okayama, Japan.

* prior to December 31,2012:From Pokka Corporation.

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